Structure of PDB 5uu1 Chain A

Receptor sequence
>5uu1A (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
PFPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVE
YQENGPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKG
RSYRFMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYV
HGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGT
IEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTA
KTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKIL
NPHGIPLGPLDFSTK
3D structure
PDB5uu1 Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7DZ A I35 G38 I43 V59 K61 P101 M121 E122 L124 L173 A185 I22 G25 I30 V46 K48 P88 M108 E109 L111 L160 A172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5uu1, PDBe:5uu1, PDBj:5uu1
PDBsum5uu1
PubMed28790404
UniProtQ86Y07|VRK2_HUMAN Serine/threonine-protein kinase VRK2 (Gene Name=VRK2)

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