Structure of PDB 5usf Chain A

Receptor sequence
>5usfA (length=682) Species: 981087 (Leishmania donovani BPK282A1) [Search protein sequence]
GSMNTDERYKLLRSVGEECIQESELRNLIEKKPLIRCYDGFEPSGRMHIA
QGIFKAVNVNKCTAAGCEFVFWVADWFALMNDKVGGELEKIRIVGRYLIE
VWKAAGMDTDKVLFLWSSEEITSHADTYWRMVLDIGRQNTIARIKKCCTI
MGKTEGTLTAAQVLYPLMQCCDIFFLKADICQLGLDQRKVNMLAREYCDL
IGRKLKPVILSHHMLAGLRRGQAKMSKSDPDSAIFMEDTEEDVARKIRQA
YCPRVKQSASAITDDGAPVATDDRNPVLDYFQCVVYARPGAVAAIDGTTY
ATYEDLEQAFVSDEVSEDALKSCLIDEVNALLAPVRQHFASNEEAHELLE
AVKSYRKGGATLPLAETALPAAPEKPHACMWMPALLKVPLDVAEGMIKAT
EDFIAAHPGGTVTVVLPDWSAVASDEITGVEKDISAALQVNCALLKAYGL
PNSVKIVTENEVILGNRNDFWVSVIGIARKNLLSHIEELYGGELRNAGQV
IAALMRVATALMLSVSHVISTSLDGHINAFAREYTKERIECVQTLEGRIP
ALHRPGAAPAVLGADDVLYLDDNDMDIRRKIKKAYSAPNEEANPVISVAQ
HLLAQHGALNIERGEANGGNVSYNTPEALVADCGSGALHPADLKAAVLQL
LLDRSAQARALLNGELKKNMTALRNAEKKMAK
3D structure
PDB5usf Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 YSA A Y36 D37 G38 E40 A48 Q49 W70 F75 Y163 Q167 D170 L181 G182 Q185 H210 M212 L213 Y38 D39 G40 E42 A50 Q51 W72 F77 Y165 Q169 D172 L183 G184 Q187 H212 M214 L215 PDBbind-CN: -logKd/Ki=9.16,IC50=0.69nM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5usf, PDBe:5usf, PDBj:5usf
PDBsum5usf
PubMed28427904
UniProtA0A3Q8ID88

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