Structure of PDB 5uqx Chain A

Receptor sequence
>5uqxA (length=346) Species: 9606 (Homo sapiens) [Search protein sequence]
KHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPL
ALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVE
NKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKK
NIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMR
FMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSG
DNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVR
HCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQK
3D structure
PDB5uqx USP7 small-molecule inhibitors interfere with ubiquitin binding.
ChainA
Resolution2.23 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N218 C223 H464 D481
Catalytic site (residue number reindexed from 1) N10 C15 H256 D273
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8JP A Q297 C300 R301 D305 E308 Y348 D349 H403 Q89 C92 R93 D97 E100 Y140 D141 H195 MOAD: Kd=246uM
PDBbind-CN: -logKd/Ki=6.21,IC50=0.61uM
BindingDB: IC50=1340nM,EC50=2580nM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5uqx, PDBe:5uqx, PDBj:5uqx
PDBsum5uqx
PubMed29045385
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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