Structure of PDB 5uqv Chain A

Receptor sequence
>5uqvA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
HTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLA
LQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVEN
KMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKN
IFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRF
MIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVV
YLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHHCTNAYMLVYIRESKL
SEVLQAVTDHDIPQQLVERLQEEKRIEAQ
3D structure
PDB5uqv USP7 small-molecule inhibitors interfere with ubiquitin binding.
ChainA
Resolution2.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N218 C223 H464 D481
Catalytic site (residue number reindexed from 1) N9 C14 H247 D264
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8JM A Q297 C300 L304 D305 E308 I320 Y348 D349 H403 Q88 C91 L95 D96 E99 I111 Y139 D140 H194 PDBbind-CN: -logKd/Ki=6.37,IC50=0.43uM
BindingDB: IC50=750nM,EC50=300nM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5uqv, PDBe:5uqv, PDBj:5uqv
PDBsum5uqv
PubMed29045385
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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