Structure of PDB 5uqr Chain A

Receptor sequence
>5uqrA (length=439) Species: 746128 (Aspergillus fumigatus) [Search protein sequence]
SGSTAEPDLKTALKAVIPAKRELFKQVKERSDEVIGEVKVANVIGGMRGL
KSMLWEGSVLDPEEGIRFHGKTIKDCQKELPKGTSGTEMLPEAMFWLLLT
GQVPSTNQVRAFSRELAEQSHLPQHILDLIKSFPRSMHPMTQLSIAVAAL
NTESKFAKAYEKGLSKADYWEPTFDDSISLLAKIPRVAALVFRPDEVDQV
GTQALDASQDWSYNFAELLGKGGKENQDFHDLLRLYLALHGDHEGGNVSA
HATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQDKIGTK
FTDDDVRNYLWDTLKSGRVVPGYGHGVLRKPDPRFQALMDFAATRPDVLA
NPVFQLVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYY
TVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLKK
3D structure
PDB5uqr Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S275 H305 H351 R360 D408
Catalytic site (residue number reindexed from 1) S249 H279 H325 R334 D382
Enzyme Commision number 2.3.3.16: citrate synthase (unknown stereospecificity).
2.3.3.5: 2-methylcitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OAA A H269 N273 H351 R360 R434 H243 N247 H325 R334 R408
Gene Ontology
Molecular Function
GO:0004108 citrate (Si)-synthase activity
GO:0016746 acyltransferase activity
GO:0036440 citrate synthase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0050440 2-methylcitrate synthase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019543 propionate catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uqr, PDBe:5uqr, PDBj:5uqr
PDBsum5uqr
PubMed31141475
UniProtQ50I20|PRPC_ASPFM 2-methylcitrate synthase, mitochondrial (Gene Name=mcsA)

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