Structure of PDB 5uqk Chain A

Receptor sequence
>5uqkA (length=537) Species: 1496 (Clostridioides difficile) [Search protein sequence]
SLISKEELIKLAYSIRPRENEYKTILTNLDEYNKLTTNNNENKYLQLKKL
NESIDVFMNKYKTSSRNRALSNLKKDILKEVILIKNSNTSPVEKNLHFVW
IGGEVSDIALEYIKQWADINAEYNIKLWYDSEAFLVNTLKKAIVESSTTE
ALQLLEEEIQNPQFDNMKFYKKRMEFIYDRQKRFINYYKSQINKPTVPTI
DDIIKSHLVSEYNRDETVLESYRTNSLRKINSNHGIDIRANSLFTEQELL
NIYSQELLNRGNLAAASDIVRLLALKNFGGVYLDVDMLPGIHSDLFKTIS
RPSSIGLDRWEMIKLEAIMKYKKYINNYTSENFDKLDQQLKDNFKLIIES
KSEKSEIFSKLENLNVSDLEIKIAFALGSVINQALISKQGSYLTNLVIEQ
VKNRYQFLNQHLNPAIESDNNFTDTTKIFHDSLFNSATAENSMFLTKIAP
YLQVGFMPEARSTISLSGPGAYASAYYDFINLQENTIEKTLKASDLIEFK
FPENNLSQLTEQEINSLWSFDQASAKYQFEKYVRDYT
3D structure
PDB5uqk Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.
ChainA
Resolution1.851 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.-
3.4.22.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U2F A V100 W101 I102 L264 S268 D269 R272 D285 T464 S517 V99 W100 I101 L263 S267 D268 R271 D284 T463 S516
BS02 MN A D287 E514 S517 D286 E513 S516
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5uqk, PDBe:5uqk, PDBj:5uqk
PDBsum5uqk
PubMed28433497
UniProtP16154|TCDA_CLODI Toxin A (Gene Name=tcdA)

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