Structure of PDB 5upv Chain A

Receptor sequence
>5upvA (length=352) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRL
KVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSG
GLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKS
EVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGA
PQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLA
GTAEAPGELIFVNGKQYKSYRGMGSLGAMRLVPEGIEGRVPFRGPLSSVI
HQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAP
NY
3D structure
PDB5upv Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis In the presence of G36
ChainA
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A S83 M85 G338 S339 I340 C341 D374 G376 G397 S398 Y421 G423 M424 G425 E458 S57 M59 G187 S188 I189 C190 D223 G225 G246 S247 Y270 G272 M273 G274 E284
BS02 8KV A M424 G425 L455 E458 M273 G274 L281 E284
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5upv, PDBe:5upv, PDBj:5upv
PDBsum5upv
PubMed
UniProtP9WKI7|IMDH_MYCTU Inosine-5'-monophosphate dehydrogenase (Gene Name=guaB)

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