Structure of PDB 5upu Chain A

Receptor sequence
>5upuA (length=332) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
DPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLK
VPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSGG
LLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSE
VGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAP
QITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAG
TAEAPGELIFVNGKQYKSYRGMGSLGAMVPEGIEGRVPFRGPLSSVIHQL
TGGLRAAMGYTGSPTIEVLQQAQFVRITPAGL
3D structure
PDB5upu Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6
ChainA
Resolution2.905 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP A S83 M85 S339 I340 C341 D374 G375 G397 S398 Y421 G423 M424 G425 E458 S56 M58 S187 I188 C189 D222 G223 G245 S246 Y269 G271 M272 G273 E281
BS02 6Q9 A D283 A285 G334 V335 G336 M424 G425 D131 A133 G182 V183 G184 M272 G273
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006164 purine nucleotide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5upu, PDBe:5upu, PDBj:5upu
PDBsum5upu
PubMed
UniProtP9WKI7|IMDH_MYCTU Inosine-5'-monophosphate dehydrogenase (Gene Name=guaB)

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