Structure of PDB 5up3 Chain A

Receptor sequence
>5up3A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERQPLHE
EIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLK
DNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFG
TSKRLTFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFY
ELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDL
LVDEFLKV
3D structure
PDB5up3 Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.
ChainA
Resolution2.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D129 K131 D133 N134 D148 T160
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8GS A L686 G687 K709 M754 E755 Q756 V757 G760 L810 S821 D822 L17 G18 K40 M80 E81 Q82 V83 G86 L136 S147 D148 PDBbind-CN: -logKd/Ki=7.90,IC50=12.59nM
BindingDB: IC50=13nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5up3, PDBe:5up3, PDBj:5up3
PDBsum5up3
PubMed28337323
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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