Structure of PDB 5uos Chain A

Receptor sequence

>5uosA (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]

SNAMEPKVAELKQKIEDTLCPFGFEVYPFQVAWYNELLPPAFHLPLPGPT
LAFLVLSTPAMFDRALKPFLQSCHLRMLTDPVDQCVAYHLGRVRESLPEL
QIEIIADYEVHPNRRPKILAQTAAHVAGAAYYYQRQDVEADPWGNQRISG
VCIHPRFGGWFAIRGVVLLPGIEVPDLPPRKPHDCVPTRADRIALLEGFN
FHWRDWTYRDAVTPQERYSEEQKAYFSTPPAQRLALLGL

3D structure

PDB

5uos Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.

Chain

Resolution

2.51 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.16.1.6: cyanocobalamin reductase.
2.5.1.151: alkylcobalamin dealkylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	B12	A	L34 L35 P36 D104 P113 I115 L116 A117 Q118 T119 H122 Y129 Q131 R144 S146 C149 I160 F196 W200	L37 L38 P39 D107 P116 I118 L119 A120 Q121 T122 H125 Y132 Q134 R147 S149 C152 I163 F199 W203
BS02	GSH	A	D77 P78 V79 D80 R161 R206 Y215 F223 R230	D80 P81 V82 D83 R164 R209 Y218 F226 R233
BS03	171	A	A84 E106	A87 E109

External links

PDB	RCSB:5uos, PDBe:5uos, PDBj:5uos
PDBsum	5uos
PubMed	28544088
UniProt	Q9Y4U1\|MMAC_HUMAN Cyanocobalamin reductase / alkylcobalamin dealkylase (Gene Name=MMACHC)

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