Structure of PDB 5unh Chain A

Receptor sequence
>5unhA (length=385) Species: 562,9606 [Search protein sequence]
ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLED
KSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNA
YIQKYLPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKKVSSIYIFN
LAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFI
TCMSVDRYQSVIYASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACI
MAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTYGKNR
ITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDL
ALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVF
3D structure
PDB5unh Structural basis for selectivity and diversity in angiotensin II receptors.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8EM A W100 Y103 L124 T125 M128 F129 T178 R182 M214 K215 W269 F272 I304 F308 W165 Y168 L189 T190 M193 F194 T232 R236 M268 K269 W321 F324 I356 F360 PDBbind-CN: -logKd/Ki=9.46,Ki=0.35nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:0042981 regulation of apoptotic process
GO:0097746 blood vessel diameter maintenance
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Molecular Function
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Cellular Component
External links
PDB RCSB:5unh, PDBe:5unh, PDBj:5unh
PDBsum5unh
PubMed28379944
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P50052|AGTR2_HUMAN Type-2 angiotensin II receptor (Gene Name=AGTR2)

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