Structure of PDB 5unf Chain A

Receptor sequence
>5unfA (length=386) Species: 562,9606 [Search protein sequence]
ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLED
KSPDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNA
HLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLL
LLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDR
YQSVIYPFPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMA
FPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNR
ITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDL
ALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
3D structure
PDB5unf Structural basis for selectivity and diversity in angiotensin II receptors.
ChainA
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8ES A Y51 W100 Y103 L124 M128 F129 T178 R182 M214 K215 F272 I304 F308 Y109 W158 Y161 L182 M186 F187 T230 R234 M266 K267 F324 I356 F360 PDBbind-CN: -logKd/Ki=9.47,Ki=0.34nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
GO:0042981 regulation of apoptotic process
GO:0097746 blood vessel diameter maintenance
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5unf, PDBe:5unf, PDBj:5unf
PDBsum5unf
PubMed28379944
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P50052|AGTR2_HUMAN Type-2 angiotensin II receptor (Gene Name=AGTR2)

[Back to BioLiP]