Structure of PDB 5und Chain A

Receptor sequence

>5undA (length=171) Species: 9606 (Homo sapiens) [Search protein sequence]

EKPFKCSMCDYASVEVSKLKRHIRSHTGERPFQCSLCSYASRDTYKLKRH
MRTHSGEKPYECYICHARFTQSGTMKMHILQKHTENVAKFHCPHCDTVIA
RKSDLGVHLRKQHSYIEQGKKCRYCDAVFHERYALIQHQKSHKNEKRFKC
DQCDYACRQERHMIMHKRTHT

3D structure

PDB

5und Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA.

Chain

Resolution

2.549 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	T391 Y392 Y407 K423 K449 S450 R457	T44 Y45 Y60 K76 K102 S103 R110
BS02	dna	A	Y358 E362 K365 R368 H369 S372 R377 Y386 R389 K393 R396 H397 T400 Q418 H425 K429 A447 R448 D451 H455 Q459 R479 Y502 Q506	Y11 E15 K18 R21 H22 S25 R30 Y39 R42 K46 R49 H50 T53 Q71 H78 K82 A100 R101 D104 H108 Q112 R132 Y155 Q159
BS03	ZN	A	C356 H369 H373	C9 H22 H26
BS04	ZN	A	C381 C384 H397 H401	C34 C37 H50 H54
BS05	ZN	A	C409 C412 H425 H430	C62 C65 H78 H83
BS06	ZN	A	C439 C442 H455 H460	C92 C95 H108 H113
BS07	ZN	A	C469 C472 H485 H489	C122 C125 H138 H142
BS08	ZN	A	H513 H517	H166 H170

External links

PDB	RCSB:5und, PDBe:5und, PDBj:5und
PDBsum	5und
PubMed	28529057
UniProt	P49711\|CTCF_HUMAN Transcriptional repressor CTCF (Gene Name=CTCF)

[Back to BioLiP]