Structure of PDB 5un2 Chain A

Receptor sequence

>5un2A (length=335) Species: 10090 (Mus musculus)

MNHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQLL
GTHSDLFVIDNSTGVVTVRSGIIIDWEAFSPPFLELLLLAEDIGQLNGTA
HLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLNGE
LVYRIEAGAQDRFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGTVP
LSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTIIANVTAIDLDL
NPKLEYHIISIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSPLNRELVAT
YEVTLSVIDNASDLPEHSVSVPNAKLTVNILDVND

3D structure

• PDB: 5un2 Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
• Chain: A
• Resolution: 2.96 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	E1947 D2005 E2007 D2041	E17 D75 E77 D111
BS02	CA	A	E1947 E2007 D2038 D2039 D2041 D2074	E17 E77 D108 D109 D111 D144
BS03	CA	A	N2040 N2042 D2072 D2074 N2078 D2125	N110 N112 D142 D144 N148 D195
BS04	CA	A	E2057 D2110 E2112 D2146	E127 D180 E182 D216
BS05	CA	A	E2057 E2112 D2143 I2144 D2146 D2179	E127 E182 D213 I214 D216 D249
BS06	CA	A	N2145 S2147 D2177 D2179 D2239	N215 S217 D247 D249 D309
BS07	CA	A	E2162 E2226 D2262 V2263	E232 E296 D332 V333
BS08	CA	A	E2162 N2224 E2226	E232 N294 E296

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0098609 cell-cell adhesion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5un2, PDBe:5un2, PDBj:5un2
• PDBsum: 5un2
• PubMed: 30033219
• UniProt: Q99PF4|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)