Structure of PDB 5ulx Chain A

Receptor sequence
>5ulxA (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKDVMTPMVDI
LMKLFRNMVNVLTLLSVCFCNLK
3D structure
PDB5ulx Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
ChainA
Resolution1.96 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A L123 E127 K207 G241 G243 Y244 K245 T246 E358 S359 L98 E102 K182 G216 G218 Y219 K220 T221 E328 S329
BS02 dna A Q59 K60 V64 L99 R103 Q300 S303 E305 S307 R347 Q34 K35 V39 L74 R78 Q275 S278 E280 S282 R322
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ulx, PDBe:5ulx, PDBj:5ulx
PDBsum5ulx
PubMed28272441
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

[Back to BioLiP]