Structure of PDB 5ulp Chain A

Receptor sequence
>5ulpA (length=262) Species: 64320 (Zika virus) [Search protein sequence]
GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHA
VSRGSAKLRWLVERGYLQPYGKVIDLGCGRGGWSYYAATIRKVQEVKGYT
KGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSP
EVEEARTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETLERLQRRYGG
GLVRVPLSRNSTHEMYWVSGAKSNTIKSVSTTSQLLLGRMDGPRRPVKYE
EDVNLGSGTRAV
3D structure
PDB5ulp Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase.
ChainA
Resolution1.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KB1 A S56 G81 G86 W87 T104 K105 H110 V130 D131 V132 F133 D146 S52 G77 G82 W83 T100 K101 H106 V126 D127 V128 F129 D142 MOAD: Kd=24.3uM
PDBbind-CN: -logKd/Ki=4.61,Kd=24.3uM
Gene Ontology
Molecular Function
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ulp, PDBe:5ulp, PDBj:5ulp
PDBsum5ulp
PubMed28487506
UniProtA0A024B7W1|POLG_ZIKVF Genome polyprotein

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