Structure of PDB 5ula Chain A

Receptor sequence
>5ulaA (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLN
LPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPG
DDIVLMAEALEKLFLQKIN
3D structure
PDB5ula BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5MJ A W81 P82 V87 L92 I146 W38 P39 V44 L49 I103 MOAD: Ki=77nM
PDBbind-CN: -logKd/Ki=7.11,Ki=77nM
External links
PDB RCSB:5ula, PDBe:5ula, PDBj:5ula
PDBsum5ula
PubMed28265070
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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