Structure of PDB 5uk5 Chain A

Receptor sequence
>5uk5A (length=194) Species: 10116 (Rattus norvegicus) [Search protein sequence]
ECQLMPNACQNGGTCHNSHGGYNCVCVNGWTGEDCSENIDDCASAACFQG
ATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAI
CTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGP
RCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCESGR
3D structure
PDB5uk5 Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
ChainA
Resolution2.506 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BGC A E455 S458 E158 S161
BS02 XYS A E455 G472 E473 E158 G175 E176
BS03 CA A N335 I336 D338 D352 R353 N38 I39 D41 D55 R56
BS04 CA A D412 V413 E415 N431 T432 G434 S435 D115 V116 E118 N134 T135 G137 S138
BS05 CA A D452 V453 E455 D469 Q470 D155 V156 E158 D172 Q173
BS06 FUC A T311 V322 T14 V25
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5uk5, PDBe:5uk5, PDBj:5uk5
PDBsum5uk5
PubMed28254785
UniProtQ07008|NOTC1_RAT Neurogenic locus notch homolog protein 1 (Gene Name=Notch1)

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