Structure of PDB 5uiv Chain A

Receptor sequence
>5uivA (length=225) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
TSARGQLILIEGLDRSGKSTQASILSTKLSPSKLIKFPDRSTPIGKLINE
YLTNKSFTLSDQAAHLLFSANRWELSQQIQDLLNQGYFIILDRYIYSGIA
YTLAKNDFHDETISQGKNKQQLNNIDWLLSPDKGLPKPDLTLFLTLDLEE
ISKRKGWGDERYELQQFQAKVKQCFLEILDTNKDPTIRIVDVGGKTIDQV
TTQLWEIIETNKNHELINDSIQFIT
3D structure
PDB5uiv The Structure of Thymidylate Kinase from Candida albicans Reveals a Unique Structural Element.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP A K35 F36 P37 R39 L51 F67 R71 R92 S96 G97 Y100 Y161 K36 F37 P38 R40 L52 F68 R72 R93 S97 G98 Y101 Y162
BS02 ADP A R14 G16 K17 S18 T19 R153 K154 T195 I196 R15 G17 K18 S19 T20 R154 K155 T196 I197
BS03 MG A D13 G155 E162 D14 G156 E163
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uiv, PDBe:5uiv, PDBj:5uiv
PDBsum5uiv
PubMed28742342
UniProtQ59TV7

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