Structure of PDB 5uil Chain A

Receptor sequence

>5uilA (length=398) Species: 28901 (Salmonella enterica)

HMKIIIAGKNDIAVNVTRWLQKKKKNIEIYAICNANDTGIDTFQRSFKKY
CKDNLIPIISLAEAYKIDDAIFLSLEFDKIVQPSKFNHNELFNIHFSYLP
KYKGMYTSAWPILNGEDTSGVTLHKIDHGIDTGAIIAQKEIIIQPFETAK
DLYEKYISEGTSLVIDNISTLLNSEYVEKEQNIKYSSYYSKKTIDYSNLE
LNFSKTAFEIINQLRAFTFREYQLPKLDGVNIFLGDVLSSRSIMKPGSIL
ERNDKEIIVSTIDYDVVLYKDNFKEILEACKYSDSKYIAKLIRAKSILFE
KNIYGWSPVIVAAYHGNIELIKWLVSKGANINDRNYKGTTVAMYFKDYML
KSGDYSGLKMLIDLGLDLTLTDYKDYTVFDYLEKSGNKNLLQYMMAFM

3D structure

• PDB: 5uil Molecular architecture of an N-formyltransferase from Salmonella enterica O60.
• Chain: A
• Resolution: 2.2 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N92 H94 T121 D130
• Catalytic site (residue number reindexed from 1): N93 H95 T122 D131

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1YJ	A	D77 K78 I79 V80 N92 M104 I125 D126 G128 D130 Y187 S189 K190	D78 K79 I80 V81 N93 M105 I126 D127 G129 D131 Y188 S190 K191
BS02	T3F	A	W305 Y313 N334 K336 T338 Y343 D346 Y380	W306 Y314 N335 K337 T339 Y344 D347 Y381
BS03	T3F	A	E75 F76 G103 M104 Y105 S107 Y195 F218 Y221 Q222	E76 F77 G104 M105 Y106 S108 Y196 F219 Y222 Q223

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004479 methionyl-tRNA formyltransferase activity
• GO:0016740 transferase activity

Biological Process

• GO:0006413 translational initiation
• GO:0009058 biosynthetic process
• GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5uil, PDBe:5uil, PDBj:5uil
• PDBsum: 5uil
• PubMed: 28263875
• UniProt: U3GK13