Structure of PDB 5uig Chain A

Receptor sequence
>5uigA (length=387) Species: 562,9606 [Search protein sequence]
MGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADI
AVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRY
IAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQCGEGQ
VACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLADLED
NWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLPEMKDFR
HGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARST
LQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAI
VLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQ
3D structure
PDB5uig Crystal structure of the adenosine A2A receptor bound to an antagonist reveals a potential allosteric pocket.
ChainA
Resolution3.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EDT A N39 N42 R102 I292 N36 N39 R99 I368
BS02 8D1 A A63 S67 V84 L85 F168 M177 L249 M270 Y271 I274 A60 S64 V81 L82 F155 M164 L325 M346 Y347 I350 PDBbind-CN: -logKd/Ki=7.95,Ki=11.2nM
Gene Ontology
Molecular Function
GO:0001609 G protein-coupled adenosine receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001973 G protein-coupled adenosine receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5uig, PDBe:5uig, PDBj:5uig
PDBsum5uig
PubMed28167788
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P29274|AA2AR_HUMAN Adenosine receptor A2a (Gene Name=ADORA2A)

[Back to BioLiP]