Structure of PDB 5ui1 Chain A

Receptor sequence
>5ui1A (length=312) Species: 9606 (Homo sapiens) [Search protein sequence]
GPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLV
ETTLKETEKITVCGDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGS
FSVEVILTLFGFKLLYPDHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQM
YELFSEVFEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQPPD
SGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNLDYIIRSH
EVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFT
AVPHPNVKPMAY
3D structure
PDB5ui1 Crystal Structure Human PP5C in Complex with an Inhibitor
ChainA
Resolution1.96 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D242 H244 D271 D274 R275 N303 H304 H352 R400 H427
Catalytic site (residue number reindexed from 1) D65 H67 D94 D97 R98 N126 H127 H175 R223 H250
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D271 N303 H352 H427 D94 N126 H175 H250
BS02 MN A D242 H244 D271 H427 D65 H67 D94 H250
BS03 8D4 A D271 R275 N303 H304 M309 Y313 R400 H427 Y451 D94 R98 N126 H127 M132 Y136 R223 H250 Y274
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5ui1, PDBe:5ui1, PDBj:5ui1
PDBsum5ui1
PubMed
UniProtP53041|PPP5_HUMAN Serine/threonine-protein phosphatase 5 (Gene Name=PPP5C)

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