Structure of PDB 5ugw Chain A

Receptor sequence
>5ugwA (length=158) Species: 9606 (Homo sapiens) [Search protein sequence]
KAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHA
CVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGP
LPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTA
LEAAANPA
3D structure
PDB5ugw Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes.
ChainA
Resolution2.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A K973 R1011 Q1018 K9 R47 Q54
BS02 GSH A C982 H983 F986 K1003 C18 H19 F22 K39
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:5ugw, PDBe:5ugw, PDBj:5ugw
PDBsum5ugw
PubMed28154186
UniProtO14746|TERT_HUMAN Telomerase reverse transcriptase (Gene Name=TERT)

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