Structure of PDB 5ugm Chain A

Receptor sequence
>5ugmA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGF
VNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSL
RKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI
EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVI
KKTETDMSLHPLLQEIYKDLY
3D structure
PDB5ugm Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8A7 A G284 C285 S289 H323 Y327 L330 I341 M364 K367 H449 L469 Y473 G78 C79 S83 H117 Y121 L124 I135 M158 K161 H243 L263 Y267
BS02 8A7 A I267 P269 L270 Q271 F287 S464 H466 I61 P63 L64 Q65 F81 S258 H260
BS03 KNA A F264 H266 R280 S342 F58 H60 R74 S136
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:5ugm, PDBe:5ugm, PDBj:5ugm
PDBsum5ugm
PubMed30575522
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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