Structure of PDB 5ugd Chain A

Receptor sequence
>5ugdA (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
PSFDCGKPQVEPKKCPVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISP
EWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRK
DIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAG
LLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPL
VCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
3D structure
PDB5ugd X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.
ChainA
Resolution1.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H603 D646 Q738 G739 D740 S741 G742
Catalytic site (residue number reindexed from 1) H58 D101 Q193 G194 D195 S196 G197
Enzyme Commision number 3.4.21.7: plasmin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 89S A F587 C588 H603 D735 S736 C737 Q738 G739 S741 T759 G762 F42 C43 H58 D190 S191 C192 Q193 G194 S196 T214 G217 PDBbind-CN: -logKd/Ki=6.62,IC50=0.24uM
BindingDB: IC50=240nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5ugd, PDBe:5ugd, PDBj:5ugd
PDBsum5ugd
PubMed29296720
UniProtP00747|PLMN_HUMAN Plasminogen (Gene Name=PLG)

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