Structure of PDB 5ufr Chain A

Receptor sequence
>5ufrA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQ
3D structure
PDB5ufr Identification and structure activity relationships of quinoline tertiary alcohol modulators of ROR gamma t.
ChainA
Resolution2.068 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 88J A Q286 L287 C320 H323 M365 F377 E379 F388 I400 Q22 L23 C56 H59 M101 F113 E115 F124 I136 MOAD: Kd=0.002uM
PDBbind-CN: -logKd/Ki=8.70,Kd=0.002uM
BindingDB: Kd=2.0nM,IC50=7.5nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ufr, PDBe:5ufr, PDBj:5ufr
PDBsum5ufr
PubMed28318945
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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