Structure of PDB 5ufp Chain A

Receptor sequence
>5ufpA (length=104) Species: 9606 (Homo sapiens) [Search protein sequence]
LDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSEN
MTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPPQCIMCVNY
VLSE
3D structure
PDB5ufp On-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 86D A F244 H248 M252 A277 Y281 M289 S292 H293 L296 S304 Y307 M309 T321 I337 C339 N341 F6 H10 M14 A39 Y43 M51 S54 H55 L58 S66 Y69 M71 T83 I95 C97 N99 PDBbind-CN: -logKd/Ki=7.37,Kd=42.5nM
BindingDB: IC50=10.0nM,EC50=6.0nM
External links
PDB RCSB:5ufp, PDBe:5ufp, PDBj:5ufp
PDBsum5ufp
PubMed27595393
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

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