Structure of PDB 5ufo Chain A

Receptor sequence
>5ufoA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMW
EMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVR
MCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSE
DEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILA
KLPPKGKLRSLCSQHVERLQIFQHL
3D structure
PDB5ufo Identification and structure activity relationships of quinoline tertiary alcohol modulators of ROR gamma t.
ChainA
Resolution2.802 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 87J A L287 C320 H323 R364 M365 F377 F378 E379 F388 L396 H479 L23 C56 H59 R100 M101 F113 F114 E115 F124 L132 H215 PDBbind-CN: -logKd/Ki=7.43,Kd=0.037uM
BindingDB: EC50=240nM,Kd=37nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ufo, PDBe:5ufo, PDBj:5ufo
PDBsum5ufo
PubMed28318945
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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