Structure of PDB 5uey Chain A

Receptor sequence
>5ueyA (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
HMEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMD
MSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDV
FEMRFAKM
3D structure
PDB5uey Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
ChainA
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 88M A W374 P375 V380 D381 L385 N433 E438 V439 W25 P26 V31 D32 L36 N84 E89 V90 MOAD: Ki=5.1nM
PDBbind-CN: -logKd/Ki=8.29,Ki=5.1nM
External links
PDB RCSB:5uey, PDBe:5uey, PDBj:5uey
PDBsum5uey
PubMed28368119
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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