Structure of PDB 5uex Chain A

Receptor sequence
>5uexA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM
DMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQD
VFEMRFAKM
3D structure
PDB5uex Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
ChainA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 89D A W374 P375 F376 V380 L385 N433 H437 E438 V439 W26 P27 F28 V32 L37 N85 H89 E90 V91 MOAD: Ki=1.5nM
PDBbind-CN: -logKd/Ki=8.82,Ki=1.5nM
External links
PDB RCSB:5uex, PDBe:5uex, PDBj:5uex
PDBsum5uex
PubMed28368119
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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