Structure of PDB 5ueu Chain A

Receptor sequence
>5ueuA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM
DMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQD
VFEMRFAKM
3D structure
PDB5ueu Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0S6 A W374 P375 F376 V380 L387 N433 V439 M442 W26 P27 F28 V32 L39 N85 V91 M94 PDBbind-CN: -logKd/Ki=7.78,Ki=16.7nM
BindingDB: Ki=17nM,IC50=18.2nM
External links
PDB RCSB:5ueu, PDBe:5ueu, PDBj:5ueu
PDBsum5ueu
PubMed28368119
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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