Structure of PDB 5udi Chain A

Receptor sequence

>5udiA (length=460) Species: 9606 (Homo sapiens) [Search protein sequence]

HQVKDSLEQLRCHFTWELSIDDDEMPDLENRVLDQIEFLDTKYSVGIHNL
LAYVKHLKGQNEEALKSLKEAENLMQEEHDNQANVRSLVTWGNFAWMYYH
MGRLAEAQTYLDKVENICKKLSNPFRYRMECPEIDCEEGWALLKCGGKNY
ERAKACFEKVLEVDPENPESSAGYAISAYRLDGFKLATKNHKPFSLLPLR
QAVRLNPDNGYIKVLLALKLQDEGQEAEGEKYIEEALANMSSQTYVFRYA
AKFYRRKGSVDKALELLKKALQETPTSVLLHHQIGLCYKAQMIQIKEATK
GQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEAGNHR
KAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIK
IEQASLTRDKSINSLKKLVLRKLRRKALDLESLSLLGFVYKLEGNMNEAE
EYYERAERLA

3D structure

PDB

5udi Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations.

Chain

Resolution

1.58 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R38 Q42 L46 T48 W147 L150 K151 Y157 I183 R187 F191 A194 N216 Y218 Y252 Y256 K259 L286 H289 Q290 L293 K336 F339 V341 D345 D379	R31 Q35 L39 T41 W140 L143 K144 Y150 I176 R180 F184 A187 N209 Y211 Y245 Y249 K252 L279 H282 Q283 L286 K329 F332 V334 D338 D372

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0005515	protein binding

	Biological Process
GO:0009615	response to virus
GO:0019060	intracellular transport of viral protein in host cell
GO:0032091	negative regulation of protein binding
GO:0045070	positive regulation of viral genome replication
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response
GO:0051097	negative regulation of helicase activity
GO:0051607	defense response to virus
GO:0051707	response to other organism
GO:0071357	cellular response to type I interferon
GO:0071360	cellular response to exogenous dsRNA
GO:0140374	antiviral innate immune response

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043657	host cell

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5udi, PDBe:5udi, PDBj:5udi
PDBsum	5udi
PubMed	28251928
UniProt	P09914\|IFIT1_HUMAN Interferon-induced protein with tetratricopeptide repeats 1 (Gene Name=IFIT1)

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