Structure of PDB 5udh Chain A

Receptor sequence
>5udhA (length=411) Species: 9606 (Homo sapiens) [Search protein sequence]
DYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLME
RYFDGNLEKLFAECHAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEY
LTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNS
FVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPV
KCKWLKKWIKKCDDANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWV
CLGPWEPHGSAWYNCNRYALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQK
MEEMQQHSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFEN
NQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHV
HEGYEKDLWEY
3D structure
PDB5udh Structural Studies of HHARI/UbcH7Ub Reveal Unique E2Ub Conformational Restriction by RBR RING1.
ChainA
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C347 C362 C367 C223 C238 C243
BS02 ZN A C372 C375 H382 C389 C248 C251 H258 C265
BS03 ZN A C276 C281 C297 C299 C161 C166 C182 C184
BS04 ZN A C304 C307 H312 C317 C189 C192 H197 C202
BS05 ZN A C186 C189 C208 C211 C71 C74 C93 C96
BS06 ZN A C203 H205 C231 C236 C88 H90 C116 C121
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5udh, PDBe:5udh, PDBj:5udh
PDBsum5udh
PubMed28552575
UniProtQ9Y4X5|ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (Gene Name=ARIH1)

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