Structure of PDB 5uci Chain A

Receptor sequence
>5uciA (length=219) Species: 9606 (Homo sapiens) [Search protein sequence]
GHMPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNAS
DALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADL
INNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITK
HNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRV
KEVVKKHSQFIGYPITLYL
3D structure
PDB5uci Structure-guided design of an Hsp90 beta N-terminal isoform-selective inhibitor.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 874 A L43 N46 A47 D49 A50 K53 D88 I91 M93 F133 T179 L45 N48 A49 D51 A52 K55 D90 I93 M95 F135 T181 PDBbind-CN: -logKd/Ki=5.37,Kd=4.27uM
BindingDB: Kd=4270nM
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:5uci, PDBe:5uci, PDBj:5uci
PDBsum5uci
PubMed29382832
UniProtP08238|HS90B_HUMAN Heat shock protein HSP 90-beta (Gene Name=HSP90AB1)

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