Structure of PDB 5uc9 Chain A

Receptor sequence
>5uc9A (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLSELLKEGTKEAHDRAENTQFVKDFLKGNIKKELFKLATTALYFTYSA
LEEEMERNKDHPAFAPLYFPMELHRKEALTKDMEYFFGENWEEQVQCPKA
AQKYVERIHYIGQNEPELLVAHAYTRYMGDLSGGQVLKKVAQRALKLPST
GEGTQFYLFENVDNAQQFKQLYRARMNALDLNMKTKERIVEEANKAFEYN
MQIFNELDQ
3D structure
PDB5uc9 Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling.
ChainA
Resolution1.903 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N50 Y78 T155 R156 G159 D160 G164
Catalytic site (residue number reindexed from 1) N20 Y48 T125 R126 G129 D130 G134
Enzyme Commision number 1.14.14.18: heme oxygenase (biliverdin-producing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MYR A L74 Y134 R156 L167 N230 F234 L44 Y104 R126 L137 N200 F204
Gene Ontology
Molecular Function
GO:0004392 heme oxygenase (decyclizing) activity
Biological Process
GO:0006788 heme oxidation

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Molecular Function
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Biological Process
External links
PDB RCSB:5uc9, PDBe:5uc9, PDBj:5uc9
PDBsum5uc9
PubMed28132836
UniProtP30519|HMOX2_HUMAN Heme oxygenase 2 (Gene Name=HMOX2)

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