Structure of PDB 5u8f Chain A

Receptor sequence
>5u8fA (length=358) Species: 9606 (Homo sapiens) [Search protein sequence]
FKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGE
IRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQ
CIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGG
VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYN
PNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCW
KPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGN
QVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDD
ASIWRWDR
3D structure
PDB5u8f SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
ChainA
Resolution1.343 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 82G A F97 Y148 L240 D310 Y365 R367 R414 F16 Y67 L159 D229 Y284 R286 R333 MOAD: Ki=11nM
PDBbind-CN: -logKd/Ki=7.96,Ki=11nM
BindingDB: Ki=11nM,Kd=10.0nM,IC50=290nM
External links
PDB RCSB:5u8f, PDBe:5u8f, PDBj:5u8f
PDBsum5u8f
PubMed28254486
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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