Structure of PDB 5u84 Chain A

Receptor sequence
>5u84A (length=352) Species: 9767 (Balaenoptera acutorostrata) [Search protein sequence]
DCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELMVDKAPALKVIVNY
LKNMINAFEPSGKIVQLVDQKLPGLLGSFPGPFEEEMKGIAAVTEIPLGE
IILFNIFYEFFTIATSIITEDKEGHLLHARNMDFGVFLGWNVNNNTWVVT
EELKPLTVNLDFQRNSKTVFKAAGFAGYVGMLTGFKPGLFSLTLNERFSG
FMGVIEWIIIRSVLENSTSYEEAKTILTKSKILAPAYFILGGSKSGEGCV
ITRDRVQSLDIYELDPKQGIWYVVQTNYDRWKNPFFLDNRRTPAKMCLNR
TTQENISFATMYDVLSTKPVLNKLTVYTALIDVTKGQFETYLRDCPDPCI
GW
3D structure
PDB5u84 Structural basis for the activation of acid ceramidase.
ChainA
Resolution2.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.23: ceramidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I3C A F351 K378 F308 K335
BS02 I3C A Y36 P37 P38 Y384 Y7 P8 P9 Y341
BS03 I3C A Y59 K60 H63 A121 V122 Y30 K31 H34 A92 V93
BS04 I3C A R193 K196 R164 K167
BS05 I3C A H63 V67 D68 V122 H34 V38 D39 V93
BS06 I3C A N134 I135 E138 F139 I252 A277 N105 I106 E109 F110 I209 A234
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0017040 N-acylsphingosine amidohydrolase activity
GO:0017064 fatty acid amide hydrolase activity
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006665 sphingolipid metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005764 lysosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5u84, PDBe:5u84, PDBj:5u84
PDBsum5u84
PubMed29692406
UniProtA0A383ZFX3|ASAH1_BALAS Acid ceramidase (Gene Name=ASAH1)

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