Structure of PDB 5u6v Chain A

Receptor sequence
>5u6vA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDL
STVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF
EFRYAKMPD
3D structure
PDB5u6v Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.
ChainA
Resolution1.775 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7WY A W370 P371 F372 V376 H433 V435 W24 P25 F26 V30 H87 V89 MOAD: ic50=21nM
PDBbind-CN: -logKd/Ki=7.68,IC50=21nM
BindingDB: Kd=0.130000nM,IC50=21nM
External links
PDB RCSB:5u6v, PDBe:5u6v, PDBj:5u6v
PDBsum5u6v
PubMed29259751
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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