Structure of PDB 5u62 Chain A

Receptor sequence

>5u62A (length=349) Species: 9606 (Homo sapiens) [Search protein sequence]

KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS
QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI
TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI
FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY
DYRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPG
KMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVG
KLYVWDLEVCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL

3D structure

PDB

5u62 Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.

Chain

Resolution

1.9 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W103 H104 S105 D109 Y154 S159 H160 P161 P177 I178 R201 L246 L315 G316 D317 L318 F372 W373 Q374 R420	W25 H26 S27 D31 Y76 S81 H82 P83 P99 I100 R123 L168 L231 G232 D233 L234 F288 W289 Q290 R329
BS02	7WD	A	F97 Y148 D310 Y365 R367	F19 Y70 D226 Y281 R283	MOAD: ic50=1.3uM PDBbind-CN: -logKd/Ki=5.89,IC50=1.3uM BindingDB: IC50=1300nM

External links

PDB	RCSB:5u62, PDBe:5u62, PDBj:5u62
PDBsum	5u62
PubMed	27992714
UniProt	O75530\|EED_HUMAN Polycomb protein EED (Gene Name=EED)

[Back to BioLiP]