Structure of PDB 5u5t Chain A

Receptor sequence

>5u5tA (length=348) Species: 9606 (Homo sapiens) [Search protein sequence]

KYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHS
QGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPI
TMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAI
FGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESY
DYFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKM
EDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKL
YVWDLEVECTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL

3D structure

PDB

5u5t Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.

Chain

Resolution

1.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W103 H104 S105 E107 D109 Y154 S159 P161 P177 R201 L246 L247 L315 G316 D317 L318 F372 W373 Q374 R420	W25 H26 S27 E29 D31 Y76 S81 P83 P99 R123 L168 L169 L229 G230 D231 L232 F286 W287 Q288 R328
BS02	7W7	A	F97 Y148 N194 D310 Y365 R367	F19 Y70 N116 D224 Y279 R281	MOAD: ic50=3.9uM PDBbind-CN: -logKd/Ki=5.41,IC50=3.9uM BindingDB: IC50=1600nM

External links

PDB	RCSB:5u5t, PDBe:5u5t, PDBj:5u5t
PDBsum	5u5t
PubMed	27992714
UniProt	O75530\|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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