Structure of PDB 5u5p Chain A

Receptor sequence

>5u5pA (length=426) Species: 10090 (Mus musculus) [Search protein sequence]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

5u5p DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.

Chain

Resolution

2.171 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1)	T80 A92 N290 R295 Q296
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	R315 N319 V321 T322 D325 T328 E354 W357 N361 A364 E396 W399 S406	R244 N248 V250 T251 D254 T257 E283 W286 N290 A293 E325 W328 S335
BS02	peptide	A	L104 S105 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 N228 W231 R238 W273	L33 S34 W71 N75 S78 G79 T80 T84 Q110 W113 N117 G120 D121 N157 W160 R167 W202

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5u5p, PDBe:5u5p, PDBj:5u5p
PDBsum	5u5p
PubMed	29175432
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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