Structure of PDB 5u39 Chain A

Receptor sequence
>5u39A (length=287) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
IKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFCRTDLDPVVEIP
ARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVP
IMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDG
FKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLR
SQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGN
SLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFED
3D structure
PDB5u39 Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H78 H237 D241 H77 H236 D240
BS02 C90 A E77 H78 T190 F191 M194 I197 L200 R201 G209 S210 V216 H237 K238 D241 H264 E76 H77 T189 F190 M193 I196 L199 R200 G208 S209 V215 H236 K237 D240 H263 BindingDB: IC50=<2.1nM,Kd=0.480000nM
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0103117 UDP-3-O-acyl-N-acetylglucosamine deacetylase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0009245 lipid A biosynthetic process
GO:0019637 organophosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5u39, PDBe:5u39, PDBj:5u39
PDBsum5u39
PubMed28549219
UniProtP47205|LPXC_PSEAE UDP-3-O-acyl-N-acetylglucosamine deacetylase (Gene Name=lpxC)

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