Structure of PDB 5u0b Chain A

Receptor sequence
>5u0bA (length=883) Species: 64320 (Zika virus) [Search protein sequence]
GETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHA
VSRGSAKLRWLEERGYLQPYGKVVDLGCGRGGWSYYAATIRKVQEVRGYT
KGGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSP
EVEETRTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETMERLQRRHGG
GLVRVPLSRNSTHEMYWVSGAKSNIIKSVSTTSQLLLGRMDGPRRPVKYE
EDVNLGSGTRAVASCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTW
AYHGSYEAPTQGSASSLVNGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQR
VFKEKVDTRVPDPQEGTRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKV
RSNAALGAIFEEEKEWKTAVEAVNDPRFWALVDREREHHLRGECHSCVYN
MMGKREKKQGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENS
GGGVEGLGLQRLGYILEEMNRAPGGKMYADDTAGWDTRISKFDLENEALI
TNQMEEGHRTLALAVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRGSG
QVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGW
DRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSN
WEEVPFCSHHFNKLYLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETA
CLAKSYAQMWQLLYFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGE
WMTTEDMLMVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIG
HRPRTTWAENIKDTVNMVRRIIGDEEKYMDYLS
3D structure
PDB5u0b Structure and function of the Zika virus full-length NS5 protein.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A S56 G81 C82 G86 T104 K105 H110 D131 V132 F133 D146 I147 S52 G77 C78 G82 T100 K101 H106 D127 V128 F129 D142 I143
BS02 ZN A E439 H443 C448 C451 E435 H439 C444 C447
BS03 ZN A H714 C730 C849 H710 C726 C845
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5u0b, PDBe:5u0b, PDBj:5u0b
PDBsum5u0b
PubMed28345656
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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