Structure of PDB 5u04 Chain A

Receptor sequence
>5u04A (length=478) Species: 64320 (Zika virus) [Search protein sequence]
LVNGVVRLLSKPWDVVTGVTVPDPQEGTRQVMNIVSSWLWKELGKRKRPR
VCTKEEFINKVRSNAEKEWKTAVEAVNDPRFWALVDREREHHLRGECHSC
VYNGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLG
YILEEMNRAPGGKMYARISKFDLENEALITNQMEEGHRTLALAVIKYTYQ
NVVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGW
DRLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVEWKPSTGWSNWEEVP
FCSHHFNKLYLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKS
YAQMWQLLYFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGEWMTTE
DMLMVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRT
TWAENIKDTVNMVRRIIGDEEKYMDYLS
3D structure
PDB5u04 Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H714 C730 C849 H305 C321 C440
BS02 ZN A E439 H443 C448 C451 E88 H92 C97 C100
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5u04, PDBe:5u04, PDBj:5u04
PDBsum5u04
PubMed28345596
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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