Structure of PDB 5tz1 Chain A

Receptor sequence
>5tz1A (length=484) Species: 5476 (Candida albicans) [Search protein sequence]
KKTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTV
YLGPKGHEFVFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKK
FAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPE
ITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYW
RRDAAQKKISATYMKEIKLRRERGDIDPNRDLIDSLLIHSTYKDGVKMTD
QEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEK
GGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNY
IVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE
VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT
IDGYKVPDPDYSSMVVLPTEPAEIIWEKRETCMF
3D structure
PDB5tz1 Structural analyses of Candida albicans sterol 14 alpha-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.154: sterol 14alpha-demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A Y118 Y132 K143 I304 G308 T311 P375 I379 R381 P462 F463 H468 C470 I471 G472 Y74 Y88 K99 I260 G264 T267 P331 I335 R337 P418 F419 H424 C426 I427 G428
BS02 VT1 A Y64 F126 F228 G307 T311 L376 H377 S378 F380 M508 Y20 F82 F184 G263 T267 L332 H333 S334 F336 M464 MOAD: Kd=20.7nM
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008398 sterol 14-demethylase activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0001766 membrane raft polarization
GO:0006696 ergosterol biosynthetic process
GO:0007032 endosome organization
GO:0016126 sterol biosynthetic process
GO:0036187 cell growth mode switching, budding to filamentous
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032541 cortical endoplasmic reticulum
GO:0097038 perinuclear endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5tz1, PDBe:5tz1, PDBj:5tz1
PDBsum5tz1
PubMed28258218
UniProtP10613|CP51_CANAL Lanosterol 14-alpha demethylase (Gene Name=ERG11)

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