Structure of PDB 5txk Chain A

Receptor sequence
>5txkA (length=317) Species: 9606 (Homo sapiens) [Search protein sequence]
AKSDTGKIGLINLGNTSYVNSILQALFMASDFRHCVLRLTENNSQPLMTK
LQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLH
EEEKTGTRICQKLKQSSSSSTSVEKMFGGKIVTRICCLCCLNVSSREEAF
TDLSLAFPPPSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVEL
SQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGRGQAYDL
CSVVVHSGVSSESGHYYCYAREGAARENQWYLFNDTRVSFSSFESVSNVT
SFFPKDTAYVLFYRQRP
3D structure
PDB5txk Expansion of DUB functionality generated by alternative isoforms - USP35, a case study.
ChainA
Resolution1.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C580 C583 C782 C785 C137 C140 C185 C188
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5txk, PDBe:5txk, PDBj:5txk
PDBsum5txk
PubMed29685892
UniProtQ9P2H5|UBP35_HUMAN Ubiquitin carboxyl-terminal hydrolase 35 (Gene Name=USP35)

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