Structure of PDB 5tx5 Chain A

Receptor sequence
>5tx5A (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
IKMKSSDFLESAELDSGGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALL
EEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTP
LSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLAS
FKMWSKLNGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYQ
QLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKF
RPFYLSQLE
3D structure
PDB5tx5 Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
ChainA
Resolution2.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 E142 N143 D156 T189
Catalytic site (residue number reindexed from 1) D127 K129 E131 N132 D145 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7MJ A V31 K45 M67 V76 L90 M92 H136 A155 D156 L157 L159 F162 V20 K34 M56 V65 L79 M81 H125 A144 D145 L146 L148 F151 PDBbind-CN: -logKd/Ki=7.80,IC50=0.016uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5tx5, PDBe:5tx5, PDBj:5tx5
PDBsum5tx5
PubMed28151659
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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