Structure of PDB 5tva Chain A

Receptor sequence
>5tvaA (length=239) Species: 63363 (Aquifex aeolicus) [Search protein sequence]
DLFSVRMRAQKNGKHVSGAERIVKKEELETAVKELLNRPKEFDFMNVKVE
KVKDFEVVKFNLKISTYSFKSPEEAREFAVKKLTQEGIKEEVAKKAVEIL
SKGANPKGGNMRGAVLMDIETGERLEEDKERGVRTIHFDWKDRKKVTEKL
LKEGYTLRTVDALALTFKNLFCGVVAELCWSDDPDYVTGYVSGKEIGYVR
ITPLKEKGDPLGGRVYFVSRKELSEIIECLTQKVVLIEL
3D structure
PDB5tva The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.14: 6-carboxyhexanoate--CoA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A M112 G114 A115 R135 T136 D183 R215 Y217 M111 G113 A114 R134 T135 D182 R214 Y216
BS02 COA A R7 R9 H16 A20 K49 R113 R132 R135 A163 R215 R6 R8 H15 A19 K48 R112 R131 R134 A162 R214 MOAD: Kd=14uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042410 6-carboxyhexanoate-CoA ligase activity
Biological Process
GO:0009102 biotin biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5tva, PDBe:5tva, PDBj:5tva
PDBsum5tva
PubMed28414711
UniProtO67575|BIOW_AQUAE 6-carboxyhexanoate--CoA ligase (Gene Name=bioW)

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