Structure of PDB 5ttu Chain A

Receptor sequence
>5ttuA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
TIFEERHLKYISQLGKGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD
FQREIQILKALHSDFIVKYRGVSYLRLVMEYLPSGCLRDFLQRHRARLDA
SRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKL
LPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTY
CDKSCSPSAEFLRMMVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCW
APSPQDRPSFSALGPQLDMLW
3D structure
PDB5ttu Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
ChainA
Resolution1.72 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D126 A128 R130 N131 D144
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7KV A L828 A853 M902 E903 L905 G908 C909 D912 L956 L14 A36 M79 E80 L82 G85 C86 D89 L133 PDBbind-CN: -logKd/Ki=7.33,IC50=47nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ttu, PDBe:5ttu, PDBj:5ttu
PDBsum5ttu
PubMed28139931
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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