Structure of PDB 5tts Chain A

Receptor sequence
>5ttsA (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQGPDQQ
RDFQREIQILKALHSDFIVKYRGVSYLRLVMEYLPSGCLRDFLQRHRARL
DASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLA
KLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELF
TYCDKSCSPSAEFLRMMVPALSRLLELLEEGQRLPAPPACPAEVHELMKL
CWAPSPQDRPSFSALGPQLDMLWS
3D structure
PDB5tts Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
ChainA
Resolution2.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D949 A951 R953 N954 D967
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7KU A A853 E903 L905 G908 C909 D912 L956 A40 E82 L84 G87 C88 D91 L135 PDBbind-CN: -logKd/Ki=7.25,IC50=56nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5tts, PDBe:5tts, PDBj:5tts
PDBsum5tts
PubMed28139931
UniProtP52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 (Gene Name=JAK3)

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